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Contact Information:

1425 NW 10th Ave
Sieron Bldg, 3rd Flr
Miami, FL-33136
V - (305) 243-4592
F - (305) 243-5577
Email -
Maria Padron

Research Grants


Recent Grants

Family Therapy Mechanisms in HIV+ Women in Drug Recovery
P.I. Victoria B. Mitrani, Ph.D.

This application proposes to investigate the family mechanisms by which Structural Ecosystems Therapy (SET; Mitrani et al, 2000) has its impact on HIV+ women in drug recovery. This proposed study is a companion to NIDA Grant DA15004 (SETA Protocol), which investigates the efficacy of SET in a clinical trial with HIV+ women who are in drug recovery. In the SETA Protocol, 176 women are randomly assigned to either SET or an HIV health group. The interventions last 4 months. SET works to transform the family system to reinforce sobriety, increase adherence with HIV medical care, and decrease sexual transmission risk behaviors in the target woman. The SETA Protocol only assesses the effect of SET on the recovering woman, not her family. Because SET targets changing the whole family as a means of helping the woman, we hypothesize that effects on the family as a whole (family functioning) and on individual family members will help to explain the woman’s outcomes. The proposed study will enroll the women in the SETA Protocol and their families. A total of 528 family members are anticipated. Families are assessed at 4-month intervals for a period of 12 months. SET is hypothesized to affect family functioning (measured by self-report and observational methods). Changes in family functioning are hypothesized to affect the woman’s drug abuse, HIV medication adherence, and HIV risk behaviors as well as the individual functioning of her family members (psychological distress, drug use and parent report of problem behaviors in children). The hypotheses will be tested using Latent Growth Curve Modeling. Understanding these mechanisms will facilitate the development of the next generation of family-based interventions for HIV+ women in drug recovery. This will be the first R01 award for this investigator.


The Florida Clinical Trials Network for Drug Abuse Treatment
NIDA 1U10 DA 13720-01
Szapocznik  09/30/2000 - 09/29/2005

A new partnership has been formed to improve the quality and impact of drug abuse treatment in Florida and throughout the country.   The Florida team consists of several top research centers at the University of Miami, led by the Center for Family Studies and its Director, Dr. José Szapocznik, and a group of the state of Florida’s top drug abuse treatment agencies, and the State of Florida.  This partnership is part of a National Clinical Trials Network established by the National Institute on Drug Abuse to improve drug abuse treatment by accelerating the transfer of proven treatment models to the front lines of treatment.
Within the University group, the Center for Family Studies is joined by the Comprehensive Drug Research Center, the Center for Treatment Research on Adolescent Drug Abuse, and the Behavioral Medicine Research Center. The treatment agencies, among the largest and most respected in the State, are Gateway Community Services, Inc. in Jacksonville (Phil Diaz, Director), Operation PAR in Pinellas Park (Nancy Hamilton, Director), the Center for Drug Free Living in Orlando (Jerry Feulner, Director), The Village in Miami (Matthew Gissen, Director), and Spectrum Programs, Inc. in Fort Lauderdale (Bruce Hayden, Director).  Together these five agencies serve over 70,000 clients per year with a combined budget of nearly $100 million. 
The Florida Clinical Trials Network brings together many of the State’s top drug abuse researchers and drug abuse treatment programs in an effort to bring state-of-the-science drug abuse treatment to the State of Florida and instantly makes Florida a national leader in the fight against drug abuse.   A third key component of the partnership is the Substance Abuse Program Office of the Florida Department of Children and Families.  Their input and leadership on the types of programs the State can fund and maintain will be critically important to the work of the Florida Clinical Trials Network.   


Families Preventing HIV in Hispanic Adolescents
NIMH 1R01 MH 63042-01
Szapocznik  09/30/2000 - 09/29/2005

Parent-adolescent communication about sexuality has been shown to be a significant factor in delaying onset of sexual activity and risky sexual behavior in adolescents. However, because of cultural taboos among Hispanics, Hispanic parents often do not speak to their children and adolescents about sexuality. This is the first research program ever funded by the NIH to study a family strengthening intervention in the prevention of HIV sexual risk behaviors among Hispanic adolescents.
This five-year $3.3 million dollar research study funded by the National Institute of Mental Health will develop and evaluate the effectiveness of two different, family-based interventions to prevent drug use and risky sexual behavior among eighth grade Hispanic adolescents. All interventions have been built on Hispanic cultural values by validating the central role of the family as protector and change agent of its youth. The study will determine if providing an HIV prevention intervention as part of a parenting program improves parent-adolescent communication, and significantly increases the effectiveness of the HIV prevention intervention in preventing adolescent drug use and risky sexual behaviors.
The study will include 300 recent immigrant Hispanic adolescents and their parents. The intervention in which a family participates will be selected at random. After completing the intervention, each family will be interviewed annually for three consecutive years.
Given Dade County’s growing Hispanic population, the researchers hope that their findings will help school and health officials deliver effective programs to prevent HIV in the Hispanic community.  Hispanics as a group are also growing rapidly in the nation. In fact, Hispanic children already are the largest child minority group in the nation.



Built Environment and Hispanic Elders’ Behavioral Health

NIMH 1R01 ES 10917-01
Szapocznik  09/30/2000 - 09/29/2005

A partnership between the University of Miami School of Medicine’s Center for Family Studies director José Szapocznik and School of Architecture faculty Joanna Lombard and Frank Martinez, Florida International University professor Frederick Newman, and Lehigh University (Pennsylvania)  professor Arnold Spokane was successful in obtaining joint funding from the National Institute of Environmental Health Sciences and the National Institute of Mental Health, both in the NIH. The study will attempt to shed light on a little-understood aspect of mental health: the impact of building architecture, street design and landscapes, and other "built environments" on the health and well-being of elderly people. The researchers hope their findings will help government officials, town planners and architects modify existing or build new residential neighborhoods that are more suitable to the health needs of the elderly.
The results of the study could have a significant economic benefit: An easing of the need to place aging baby-boomers in costly nursing homes. Do some types of neighborhoods contribute more significantly than others to the decline of the elderly? That is what the study will try to determine.
The impact of architecture and other built environments on human behavior has been studied for some time. School of Architecture Dean Elizabeth Plater-Zyberk is one of the founders of a theory and movement called New Urbanism, which suggests that small neighborhoods, with residences placed close to each other with greater variability of use, foster a greater sense of social connection and increased social interaction. However, few studies exist on the impact of the built environment on the health and well being of the elderly.  This is the first time the National Institutes of Health recognizes the built environment, as defined by New Urbanism Theory, as a potential health risk.
The study will investigate four aspects of the built environment believed to affect social behavior: the diversity of use of buildings (whether they serve multiple purposes); building types (including walk-ups, low-rises and high-rises, and multiple-family housing with courtyards and front steps or with side-yards); street block dimensions and landscape (including the space between buildings and streets that impacts on pedestrian convenience, comfort and traffic control) and the use of open space (whether it provides opportunities for people to socialize).
Researchers will interview 400 randomly selected Hispanic men and women who are 70 years or over. Each will be interviewed annually for 4 consecutive years to determine rate of decline in health and capacity to perform everyday tasks (e.g., using a phone or writing a check). 
The residents will represent the "full spectrum" of built environments in East Little Havana, a community of 40,500 mostly Hispanic residents.  The researchers want to determine whether these elderly feel connected to their community.  A special concern is when elderly individuals in low-income neighborhoods such as East Little Havana become isolated and house-bound, reluctant to seek out support systems because they fear to leave the safety of their homes. The study will look at such factors as whether the buildings are accessible and whether they are near grocery stores, medical offices and other types of services critical to the elderly.
East Little Havana was chosen for the study, in part, because architectural and other data of the community exists as the result of an earlier study, relating to adolescent drug use. For this study on the elderly, the researchers will use a statistical method applicable to any neighborhood, regardless of its social, ethnic and economic characteristics.


Developing a Culturally Rooted Family Therapy for Hispanic Adolescents

NIDA 1R01 DA 13104
Santisteban  08/01/2000 - 07/31/2004

This new study has been awarded to Dr. Daniel Santisteban, Associate Professor of Psychology and a Clinical Psychologist at the University of Miami Center for Family Studies, by the National Institute on Drug Abuse.  Dr. Santisteban’s work is designed to learn more about the unique values, acculturation, and immigration-related life experiences of Hispanic adolescents and families and how these values and experiences impact the development and treatment of adolescent drug abuse.  The final product of this study will be a drug abuse treatment model specifically refined and enhanced for use with Hispanic adolescents and their families.  The treatment model will more effectively utilize the strengths of the Hispanic family and will more precisely address their unique stressful life experiences. 


Clinical Processes in Drug Abuse Prevention

Little research has been conducted on what actually happens during prevention intervention.  This study examines in-session behaviors in drug abuse prevention intervention groups.  The primary goal of this study is to initiate a program of research that will increase understanding about how clinicians influence within-session participant behaviors and group processes, which, in turn, influence outcomes (“Attendance”, “Parental Involvement”).  With this understanding, prevention clinicians can be trained to be more effective.



Earlier Grants

Borderline Adolescent Family Therapy
NIDA 1R01 DA 11061
Santisteban  04/01/1997 - 03/31/2000

This study conducts a Stage 1 treatment development study targeting a subtype of drug abusing adolescents, Borderline Personality Disorder (BPD), that have proved to be particularly difficult to treat. The proposed intervention, Borderline Adolescent Family Therapy (BAFT) integrates two successful traditions in intervention research: Structural Family Therapy for drug abusing adolescents with individual skills building components derived from the work of Marsha Linehan with Borderline. The study includes a family therapy process component followed by a pilot test with random assignment that will yield preliminary efficacy data (N=20).


Structural Ecosystems Therapy with HIV+ African American Women

NIMH55796
Szapocznik  09/30/1995 - 04/30/2000


This is a randomized trial that examines the efficacy of Structural Ecosystems Therapy in improving family functioning and reducing distress and other psychosocial sequelea of HIV infection. The sample consists of African American women (N=206) living in Dade County, Florida who have tested positive for HIV-1. The study participants are randomly assigned to either the Structural Ecosystems Therapy condition, a Person Centered Approach therapy condition, or a Community Control. Data from this multiple time-series mixed design intervention will be analyzed using structural equation modeling and hierarchical linear models.


Enhancing Family Caregiving for ADRD
NIA 1V01AG 13297
Eisdorfer  10/01/1995 - 09/30/2000


This is a randomized trial that examines the efficacy of an innovative Family-based Structural Multisystems in-home Intervention (FSMI) developed by Dr. Szapocznik as well as the innovate combination of Family-based Structural Multisystems in-home Intervention and a Computer Telephone Integration System (CTIS). The sample consists of 200 Cuban American or Caucasian-Caregivers of Alzheimer’s patients. The study uses an experimental design in which families are randomized to three conditions; 1) FSMI, 2) FSMI + CTIS, and 3) Control outcomes include caregiver burden, distress and family functioning. Data from this multiple time-series design will be analyzed using random regression models, structural equations modeling and hierarchical linear models.


Structural Ecosystems Prevention Intervention Study (SEPI)

SHAMSA/CSAP 07961
Szapocznik/Coatsworth  09/30/1996 - 09/30/2000


This project is a randomized trial that examines the effectiveness of Structural Ecosystems Prevention Intervention on increasing parental involvement and investment on the target child, increasing social competence and self-regulation and control and decreasing rates of behavioral problems and drug use. The sample consist of 12 year old African American (N=81) and Hispanic (N=167) adolescents. Adolescents are randomly assigned to either the Structural Ecosystems Prevention Intervention or to a control condition. Data from this multiple time-series mixed design will be analyzed using random regression models, structural equation modeling and hierarchical linear models.


Structural Ecosystems Therapy with Drug Using Minority Youth

NIDA DA 10574
Szapocznik  09/30/1996 - 07/31/2001


This is a randomized trial that examines the efficacy of Structural Ecosystems Therapy in improving family and ecosystemic functioning and reducing drug use and behavioral problems in the youth. The sample consists of African American (N=100) and Hispanic (N=100) drug using adolescents. Adolescents are randomly assigned to one of three treatment conditions: Structural Ecosystems Therapy, Structural Family Therapy, or Community Control. Data from this multiple time-series mixed design will be analyzed using structural equation modeling and hierarchical linear models.



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